Examination of Critical Greek Texts of the New Testament Through Word Study of Therapeuo

This project seeks to examine the idea of healthcare within the New Testament of the Bible. A word study of the most prevalent Greek word for healing in the New Testament, therapueo, was done to illuminate the meanings behind these scriptural examples of healing. Five passages that included verses surrounding occurrences of therapeuo were selected to be translated. Four of these passages were from the book of Luke and the fifth was from Acts. The report consists of two parts. The first will discuss the word study conducted on therapeuo exclusively, and the second will expand on some of the portions of the translated passages that stood out regarding healing. The definition and use of therapeuo was found to be a very broad term for healing of many different types, according to the word study. Many other phrases and language used stood out in the translations and these were further examined in the second part of the report. It was concluded that the word study of therapeuo was thorough, but other types of healing, and other words for healing, should be studied in order to gain a more complete depiction of healing in the New Testament

Sepsis is associated with an upregulation of functional beta3 adrenoceptors in the myocardium.

OBJECTIVE: To analyze the implication of the beta3-adrenoceptor (beta3-AR) pathway in human septic myocardium and a murine model of sepsis, a condition associated with myocardial depression. METHODS AND RESULTS: beta3-AR and eNOS protein abundance were increased (332+/-66.4% and 218+/-39.3; P<0.05) in hearts from septic patients. The effect of BRL37344, a beta3-AR-preferential agonist, was analyzed by videomicroscopy on the contractility of neonatal mouse ventricular myocytes (NMVM) incubated with conditioned medium from LPS-stimulated cultured macrophages (Mc-LPS+ medium). Stimulation of untreated NMVM with BRL37344 dose-dependently decreased the amplitude of contractile shortening (P<0.05). This response was abolished by L-NAME (NOS inhibitor). Incubation in Mc-LPS+ medium potentiated the depressing effect of BRL37344 (P<0.05) as well as of SR58611A (P<0.05) in wild-type myocytes. Importantly, the contractile depression was abrogated in cardiomyocytes from beta3-AR KO mice. CONCLUSIONS: beta3-AR are upregulated during sepsis in the human myocardium and by cytokines in murine cardiomyocytes, where they mediate an increased negative inotropic response to beta3 agonists. Activation of the beta3-AR pathway by catecholamines may contribute to the myocardial dysfunction in sepsis